Antigenemia is associated with low antibody response to carbohydrate determinants of a filarial surface antigen.
Identifieur interne : 008F39 ( Main/Exploration ); précédent : 008F38; suivant : 008F40Antigenemia is associated with low antibody response to carbohydrate determinants of a filarial surface antigen.
Auteurs : M S Bal [Inde] ; M K Beuria ; N N Mandal ; M K DasSource :
- Parasite immunology [ 0141-9838 ] ; 2003.
Descripteurs français
- KwdFr :
- Adolescent, Adulte d'âge moyen, Animaux, Anticorps antihelminthe (immunologie), Anticorps antihelminthe (sang), Antigènes d'helminthe (), Antigènes d'helminthe (analyse), Antigènes de surface (), Antigènes de surface (immunologie), Filariose lymphatique (diagnostic), Filarioses (immunologie), Glucides (analyse), Glucides (immunologie), Humains, Hydrocèle (diagnostic), Immunoglobuline G (sang), Maladies endémiques, Mâle, Production d'anticorps, Wuchereria bancrofti (immunologie), Épitopes ().
- MESH :
- analyse : Antigènes d'helminthe, Glucides.
- diagnostic : Filariose lymphatique, Hydrocèle.
- immunologie : Anticorps antihelminthe, Antigènes de surface, Filarioses, Glucides, Wuchereria bancrofti.
- sang : Anticorps antihelminthe, Immunoglobuline G.
- Adolescent, Adulte d'âge moyen, Animaux, Antigènes d'helminthe, Antigènes de surface, Humains, Maladies endémiques, Mâle, Production d'anticorps, Épitopes.
English descriptors
- KwdEn :
- Adolescent, Animals, Antibodies, Helminth (blood), Antibodies, Helminth (immunology), Antibody Formation, Antigens, Helminth (analysis), Antigens, Helminth (chemistry), Antigens, Surface (chemistry), Antigens, Surface (immunology), Carbohydrates (analysis), Carbohydrates (immunology), Elephantiasis, Filarial (diagnosis), Endemic Diseases, Epitopes (chemistry), Filariasis (immunology), Humans, Immunoglobulin G (blood), Male, Middle Aged, Testicular Hydrocele (diagnosis), Wuchereria bancrofti (immunology).
- MESH :
- chemical , analysis : Antigens, Helminth, Carbohydrates.
- chemical , blood : Antibodies, Helminth, Immunoglobulin G.
- chemical , chemistry : Antigens, Helminth, Antigens, Surface, Epitopes.
- chemical , immunology : Antibodies, Helminth, Antigens, Surface, Carbohydrates.
- diagnosis : Elephantiasis, Filarial, Testicular Hydrocele.
- immunology : Filariasis, Wuchereria bancrofti.
- Adolescent, Animals, Antibody Formation, Endemic Diseases, Humans, Male, Middle Aged.
Abstract
The IgG response to a filarial surface antigen (DssdI) was evaluated in circulating antigen (Og4C3 test) positive and negative individuals from the Wuchereria bancrofti endemic region of Orissa, India. Circulating filarial antigen (CFA) positive individuals exhibited depressed antibody levels to DssdI and individuals with high antibody levels were invariably CFA negative. Low IgG levels to DssdI are associated with CFA positivity irrespective of microfilaraemia and clinical status. Thus asymptomatic microfilaraemic individuals with antigen positivity exhibited low IgG levels similar to symptomatic (chronic filariasis with elephantiasis, hydrocele) or asymptomatic amicrofilaraemic individuals with antigenemia. Western blot analysis revealed a band of approximately 210 kDa reactive with CFA-negative, but not with CFA-positive sera. DssdI was subjected to mild periodate oxidation to investigate the role of carbohydrate epitopes. The treatment considerably reduced the antigenic recognition of DssdI, stressing the immunodominance of carbohydrate residues of DssdI in infection-free individuals. In contrast, individuals with active infection failed to produce such antibodies to filarial surface carbohydrates.
PubMed: 12791107
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 004249
- to stream PubMed, to step Curation: 004249
- to stream PubMed, to step Checkpoint: 004249
- to stream Ncbi, to step Merge: 000D71
- to stream Ncbi, to step Curation: 000D71
- to stream Ncbi, to step Checkpoint: 000D71
- to stream Main, to step Merge: 009247
- to stream Main, to step Curation: 008F39
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antigenemia is associated with low antibody response to carbohydrate determinants of a filarial surface antigen.</title><author><name sortKey="Bal, M S" sort="Bal, M S" uniqKey="Bal M" first="M S" last="Bal">M S Bal</name><affiliation wicri:level="1"><nlm:affiliation>Immunology Division, Regional Medical Research Centre (ICMR), Chandrasekharapur, Bhubaneswar - 751023, Orissa, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Immunology Division, Regional Medical Research Centre (ICMR), Chandrasekharapur, Bhubaneswar - 751023, Orissa</wicri:regionArea><wicri:noRegion>Orissa</wicri:noRegion></affiliation></author><author><name sortKey="Beuria, M K" sort="Beuria, M K" uniqKey="Beuria M" first="M K" last="Beuria">M K Beuria</name></author><author><name sortKey="Mandal, N N" sort="Mandal, N N" uniqKey="Mandal N" first="N N" last="Mandal">N N Mandal</name></author><author><name sortKey="Das, M K" sort="Das, M K" uniqKey="Das M" first="M K" last="Das">M K Das</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:12791107</idno><idno type="pmid">12791107</idno><idno type="wicri:Area/PubMed/Corpus">004249</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">004249</idno><idno type="wicri:Area/PubMed/Curation">004249</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">004249</idno><idno type="wicri:Area/PubMed/Checkpoint">004249</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">004249</idno><idno type="wicri:Area/Ncbi/Merge">000D71</idno><idno type="wicri:Area/Ncbi/Curation">000D71</idno><idno type="wicri:Area/Ncbi/Checkpoint">000D71</idno><idno type="wicri:doubleKey">0141-9838:2003:Bal M:antigenemia:is:associated</idno><idno type="wicri:Area/Main/Merge">009247</idno><idno type="wicri:Area/Main/Curation">008F39</idno><idno type="wicri:Area/Main/Exploration">008F39</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Antigenemia is associated with low antibody response to carbohydrate determinants of a filarial surface antigen.</title><author><name sortKey="Bal, M S" sort="Bal, M S" uniqKey="Bal M" first="M S" last="Bal">M S Bal</name><affiliation wicri:level="1"><nlm:affiliation>Immunology Division, Regional Medical Research Centre (ICMR), Chandrasekharapur, Bhubaneswar - 751023, Orissa, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Immunology Division, Regional Medical Research Centre (ICMR), Chandrasekharapur, Bhubaneswar - 751023, Orissa</wicri:regionArea><wicri:noRegion>Orissa</wicri:noRegion></affiliation></author><author><name sortKey="Beuria, M K" sort="Beuria, M K" uniqKey="Beuria M" first="M K" last="Beuria">M K Beuria</name></author><author><name sortKey="Mandal, N N" sort="Mandal, N N" uniqKey="Mandal N" first="N N" last="Mandal">N N Mandal</name></author><author><name sortKey="Das, M K" sort="Das, M K" uniqKey="Das M" first="M K" last="Das">M K Das</name></author></analytic><series><title level="j">Parasite immunology</title><idno type="ISSN">0141-9838</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Animals</term><term>Antibodies, Helminth (blood)</term><term>Antibodies, Helminth (immunology)</term><term>Antibody Formation</term><term>Antigens, Helminth (analysis)</term><term>Antigens, Helminth (chemistry)</term><term>Antigens, Surface (chemistry)</term><term>Antigens, Surface (immunology)</term><term>Carbohydrates (analysis)</term><term>Carbohydrates (immunology)</term><term>Elephantiasis, Filarial (diagnosis)</term><term>Endemic Diseases</term><term>Epitopes (chemistry)</term><term>Filariasis (immunology)</term><term>Humans</term><term>Immunoglobulin G (blood)</term><term>Male</term><term>Middle Aged</term><term>Testicular Hydrocele (diagnosis)</term><term>Wuchereria bancrofti (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Anticorps antihelminthe (immunologie)</term><term>Anticorps antihelminthe (sang)</term><term>Antigènes d'helminthe ()</term><term>Antigènes d'helminthe (analyse)</term><term>Antigènes de surface ()</term><term>Antigènes de surface (immunologie)</term><term>Filariose lymphatique (diagnostic)</term><term>Filarioses (immunologie)</term><term>Glucides (analyse)</term><term>Glucides (immunologie)</term><term>Humains</term><term>Hydrocèle (diagnostic)</term><term>Immunoglobuline G (sang)</term><term>Maladies endémiques</term><term>Mâle</term><term>Production d'anticorps</term><term>Wuchereria bancrofti (immunologie)</term><term>Épitopes ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antigens, Helminth</term><term>Carbohydrates</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Helminth</term><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antigens, Helminth</term><term>Antigens, Surface</term><term>Epitopes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Helminth</term><term>Antigens, Surface</term><term>Carbohydrates</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Antigènes d'helminthe</term><term>Glucides</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Testicular Hydrocele</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Filariose lymphatique</term><term>Hydrocèle</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antihelminthe</term><term>Antigènes de surface</term><term>Filarioses</term><term>Glucides</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Filariasis</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antihelminthe</term><term>Immunoglobuline G</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Animals</term><term>Antibody Formation</term><term>Endemic Diseases</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Antigènes d'helminthe</term><term>Antigènes de surface</term><term>Humains</term><term>Maladies endémiques</term><term>Mâle</term><term>Production d'anticorps</term><term>Épitopes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The IgG response to a filarial surface antigen (DssdI) was evaluated in circulating antigen (Og4C3 test) positive and negative individuals from the Wuchereria bancrofti endemic region of Orissa, India. Circulating filarial antigen (CFA) positive individuals exhibited depressed antibody levels to DssdI and individuals with high antibody levels were invariably CFA negative. Low IgG levels to DssdI are associated with CFA positivity irrespective of microfilaraemia and clinical status. Thus asymptomatic microfilaraemic individuals with antigen positivity exhibited low IgG levels similar to symptomatic (chronic filariasis with elephantiasis, hydrocele) or asymptomatic amicrofilaraemic individuals with antigenemia. Western blot analysis revealed a band of approximately 210 kDa reactive with CFA-negative, but not with CFA-positive sera. DssdI was subjected to mild periodate oxidation to investigate the role of carbohydrate epitopes. The treatment considerably reduced the antigenic recognition of DssdI, stressing the immunodominance of carbohydrate residues of DssdI in infection-free individuals. In contrast, individuals with active infection failed to produce such antibodies to filarial surface carbohydrates.</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><noCountry><name sortKey="Beuria, M K" sort="Beuria, M K" uniqKey="Beuria M" first="M K" last="Beuria">M K Beuria</name><name sortKey="Das, M K" sort="Das, M K" uniqKey="Das M" first="M K" last="Das">M K Das</name><name sortKey="Mandal, N N" sort="Mandal, N N" uniqKey="Mandal N" first="N N" last="Mandal">N N Mandal</name></noCountry><country name="Inde"><noRegion><name sortKey="Bal, M S" sort="Bal, M S" uniqKey="Bal M" first="M S" last="Bal">M S Bal</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 008F39 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 008F39 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:12791107
|texte= Antigenemia is associated with low antibody response to carbohydrate determinants of a filarial surface antigen.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:12791107" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |